This model implements the UVA/Padova model equations published by Dalla Man et al. in [1-4], but has been adapted such that the simulation output accurately matches that of the UVA/PADOVA Type 1 Diabetes Simulator (T1DMS) [5].
Specifics and deviations
The following summary has been taken from [6]:
Block diagram
The following scheme visualizes the state variables (“compartments”) as circles and the interactions between them (important signals are depicted in rectangles):
Disclaimer
It must be expressly pointed out that this is only a mathematical model which can at most describe the real processes in the human body approximately and in parts. Therefore, although the simulation results qualitatively resemble clinical curves, they must be interpreted with caution and are not suitable for deriving individual treatment strategies from them (see disclaimer). We do not assume any responsibility for the correctness of the results or damages of any kind resulting from the use of the simulator (see license).
References
[1] Dalla Man, Ch.; Camilleri, M.; Cobelli, C.: A System Model of Oral Glucose Absorption: Validation on Gold Standard Data. IEEE Transactions on Biomedical Engineering, Volume 53, Number 12, December 2006
[2] Dalla Man, Ch.; Raimondo, D.M.; Rizza, R. A.; Cobelli, C.: GIM, Simulation Software of Meal Glucose-Insulin Model. Journal of Diabetes Science and Technology, Volume 1, Issue 3, May 2007
[3] Dalla Man, C.; Rizza, R. A.; Cobelli, C.: Meal simulation model of the glucose-insulin system. IEEE Transactions on biomedical engineering, 54(10), 2007.
[4] Dalla Man, C.; Micheletto, F.; Lv, D.; Breton, M.; Kovatchev, B.; Cobelli, C.: The UVA/PADOVA Type 1 Diabetes Simulator: New Features. Journal of Diabetes Science and Technology, Volume 8, Issue 1, 2014.
[5] The University of Virginia. T1DMS (version 3.2) [Software]. 2008, 2014. Retrieved from https://tegvirginia.com/.
[6] Eichenlaub, M., Freckmann, G., Schrills, T., Reenberg, A.T., Ritschel, T., Jørgensen, J., Lüddeke, H.-J., Hohm, S., Seidler, I., Schmitzer, J., Betz, H., Blechschmidt, R.,
and Peuscher, H. (2023). A numerical comparison of the UVA/Padova type 1 diabetes simulator and the open-source simulator LT1. e-Poster at ATTD 2023.
The design of the block diagram was inspired by Clara Furió Novejarque et al. doi:10.1016/j.ifacol.2022.09.169.